New heterocyclic compounds from 1,2,4-Triazoles class with potential cytotoxic activity

Abstract

Acylhydrazinecarbothioamides (2a,b) were synthesized by addition of 2-(5H-dibenzo[a,d][7]annulen-5- yl)acetohydrazide to different isothiocyanates. The new 1,2,4-Triazol-3-Thioles (3a,b) were synthesized by cyclization of new 2-Acylhydrazinecarbothioamides (3a,b) in basic media. Alkylation of 1,2,4-Triazole-3-Thiols (3a-c) with ethyl bromide gave only S-substituted derivatives (4a-c). The structures of the synthesized compounds have been established on spectral data (IR, 1H-NMR and 13C-NMR spectroscopy) and elemental analysis. The cytotoxic effect of new compounds was evaluated using two alternative models on plant and invertebrate organisms.