Carrier state of Typhoid fever patient after treatment with chloramphenicol

Abstract

Objective: to know the incidence of carrier state of typhoid patient after treatment with Chlomphenicol (Post therapy carrier) Design: Uncontrolled survey Setting: Department of Internal Medicine General Hospital of Palembang 30 patients with positive Salmonella culture Patients: Chloramphenicol 4 × 500 mg per oral for two weeks. Intervention: Reculture of Salmonella from blood and stool on day 15 (after cessation of the treatment) Measurements: Mean of age was 23.9 ± 9.9 years -Length of fever before admission was 6.8 ± 1.8 days -Average of body temperature on admission was 38.7 ±0.7 °C -Fever disappeared on day 4.7 ± 1.0 from the beginning of the treatment -After treatment, the total number of negative results of Salmonella culture were 30 of thirty patients observed (100%) Conclusion: There was not any post therapy carrier among the typhoid patients we observed, after treatment with chloramphenicol.