Spray: Film Forming System Promising as Transdermal Drug Delivery System

Abstract

Transdermal drug delivery systems offer numerous advantages over conventional routes, including improved patient compliance and reduced systemic side effects. Spray-on film forming systems (SFFS) have emerged as a novel and versatile approach for delivering drugs through the skin. This abstract presents an overview of SFFS technology, highlighting its potential in transdermal drug delivery. SFFS formulations consist of a solution or suspension of drug molecules and polymers, which upon spraying onto the skin, form a thin, uniform film that adheres to the application site. This film acts as a reservoir for drug release, providing controlled and sustained delivery over time. The versatility of SFFS allows for the incorporation of various drugs, including small molecules, peptides, and proteins, catering to a wide range of therapeutic needs. Moreover, SFFS offers advantages such as ease of application, improved bioavailability, and enhanced skin permeation compared to traditional dosage forms. This abstract summarizes recent advancements in SFFS technology, including formulation strategies, characterization methods, and in vitro/in vivo evaluations. Additionally, challenges such as skin irritation, film integrity, and scalability are discussed, along with potential solutions. Overall, SFFS holds great promise as a transdermal drug delivery system, offering opportunities for enhanced therapeutic outcomes and patient convenience.