Cognitive Effect of the Sub-Chronic Exposure to Mosquito Coil Smoke in Mice

Abstract

The aim of this experiment is to investigate the cognitive effect of the sub-chronic exposure to mosquito coil smoke in mice. A total of 28 adult mice were used. The mice were divided into four groups. Group 1 served as a control group and got exposed to environment air, while group 2, 3 and 4 were exposed to 1 hour, 2 hours and 3 hours of mosquito coil smoke respectively for 6 weeks. Learning and memory test were conducted after 1 week, 3 weeks and 6 weeks of exposure. The brains were harvested, homogenized and samples analysed for Malondialdehyde (MDA) and Acetylcholinestrase (AChE). The result showed that mosquito coil smoke significantly (P˂0.05) decrease Learning and Memory. Oxidative stress might have played role in the decreased Learning and Memory. This study indicates the toxic effect of mosquito coil smoke.