Synthesis, antioxidant, and cytotoxic activities of n-azole substituted thiomorpholine Derivatives

Abstract

A new class of N-azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 μM, respectively. A new series of N-azole substituted thiomorpholine derivatives were prepared to study their antioxidant and cytotoxic activities. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited excellent radical scavenging activity greater than ascorbic acid. The thiazolyl thiomorpholine 10c showed noticeable cytotoxic activity against A549 and HeLa cells. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.