New drug delivery system

Abstract

Background: Local drug delivery has always been chosen as a better treatment protocol over systemic therapy to avoid any systemic effects, maximize efficacy and minimize systemic side effects. Mouthwashes, suspensions, paints, lozenges, ointments, gels and toothpastes etc have been various modes of delivery researched upon. With the reign of materials used in dentistry, denture resin having been the most commonly and frequently used material was chosen to study the application of drug delivery. Aim and Objective: The aim of the study is to ensure the drug leaching activity, the effect of modulation of concentration of the drug on the microbial inhibitory activity, as well as the efficacy as compared to the pure form of the drug. Material and Method: Three experimental groups were chosen which were as follows: the first group the denture resin was impregnated with 150gm of Fluconazole powder; the second group the denture resin was impregnated using 300gm of Fluconazole powder, whereas the third group was used as control which contained 10mcg Fluconazole paper disc. The three discs, one from each group was placed over Sabouraud Dextrose Agar medium containing C.Albican species and cultured for 24 hours at 30 °C. The readings were noted after 24 hours to measure the zone of inhibition. The readings were again taken after 48 hours to re-establish the efficacy. Results: The results of our study reported gradually increasing leaching activity over 48 hrs. 60mcg concentration of the drug concentration in the disc showed similar effects as compared to 10mcg of the pure drug. Conclusion: Within the limitations of the present investigation resin system can be used for intraoral delivery of antifungal drugs. The concentration of the drug mixed with the denture material can be modulated to achieve the desired concentration of the drug acting at the local site.