Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells

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Abstract

Immuno-modulatory effects of infant gut bacteria were tested on poly(I:C) stimulated HT-29 intestinal epithelial cells. Blautia producta, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides thetaiotaomicron decreased transcription of poly(I:C)-induced inflammatory genes. Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.

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Pathmanathan, S. G., Lawley, B., McConnell, M., Baird, M. A., & Tannock, G. W. (2020). Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells. Anaerobe, 61. https://doi.org/10.1016/j.anaerobe.2019.102112

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