The interdependence of transcript and protein abundance: new data–new complexities

Abstract

The relative contribution of transcriptional and translational regulation in gene expression control has been intensely debated and remains a challenging question. Recent reports have suggested that protein abundance in mammalian cells is primarily controlled at the transcript‐level. In their recent work, Cheng et al ( ) determined the proteomic and transcriptomic changes in cells responding to endoplasmic reticulum ( ER ) stress. Their analyses indicate that the ER stress response is significantly controlled at both the transcript and protein levels.