We examined the role of the orphan nuclear hormone receptor CoupTFI in mediating cortical development downstream of meningeal retinoic acid signaling. CoupTFI is a regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems. To examine the interaction of CoupTFI and cortical RA signaling we utilized Foxc1-mutant mice in which defects in meningeal development lead to alterations in cortical development due to a reduction of RA signaling. By analyzing CoupTFI-/-;Foxc1H/L double mutant mice we provide evidence that CoupTFI is required for RA rescue of the ventricular zone and the neurogenic phenotypes in Foxc1-mutants. We also found that overexpression of CoupTFI in Foxc1-mutants is sufficient to rescue the Foxc1-mutant cortical phenotype in part. These results suggest that CoupTFI collaborates with RA signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis. © 2013 Harrison-Uy et al.
CITATION STYLE
Harrison-Uy, S. J., Siegenthaler, J. A., Faedo, A., Rubenstein, J. L. R., & Pleasure, S. J. (2013). CoupTFI Interacts with Retinoic Acid Signaling during Cortical Development. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0058219
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