Synthesis, spectral investigation and biological interphase of drug-based cytotoxic square pyramidal coordination compounds

Abstract

We have synthesized ciprofloxacin-based metal complexes of bipyridine derivatives [Cu(CFL)(A n)Cl].2H 2O (where CFL=ciprofloxacin and A=bipyridines e.g. A 1=4-(4-fluorophenyl)-6-p-tolyl-2,2′- bipyridine, A 6=4-(4-(benzyloxy)phenyl)-6-(4-bromophenyl)-2,2′- bipyridine, etc.). The ligands and complexes were characterized using analytical (C, H, N elemental analysis, TGA and magnetic measurement) and spectroscopic methods ( 1H and 13C NMR, FT-IR, fast atom bombardment mass and reflectance spectroscopy). The products were evaluated by screening for DNA interaction activity on herring sperm DNA and studies suggest intercalative mode of DNA binding. The antimicrobial activity was determined in terms of minimum inhibitory concentration. Superoxide dismutase mimic studies were performed using the NADH/PMS/NBT system. The brine shrimp bioassay was also carried out to study the in vitro cytotoxic properties of the synthesized metal complexes. © 2012 John Wiley & Sons, Ltd.