EFFECT OF NOISE STRESS-INDUCED NEUROBEHAVIORAL CHANGES ON WISTAR ALBINO RATS

Abstract

Objective: The study aims to investigate the effect of acute noise stress on cognitive functions in male Wistar albino rats. Methods: Adult albino rats were randomly divided into two groups. Each group contains six animals. Rats exposed to acute noise stress (100 dB/4 h) were compared with control animal and assessed for cognition using T-maze, hole-board test, open-field test, marble burying test, and social interaction behavior. Results: The rats exposed to acute noise stress showed the significance (p<0.05) of behavioral alterations such as impaired learning and memory, memory retention, increased fear and anxiety, obsessive–compulsive behavior, social avoidance, and decreased social interaction. Conclusion: The results report that acute noise stress affects the cognition, and it became chronic may confer the increased risk of neurodegenerative disorders.