Reply to Gilchrist et al.: Possible roles for VAC14 in multiple infectious diseases

Abstract

Our studies of the SNP rs8060947 determine that the A allele is associated with increased invasion of Salmonella enterica serovar Typhi and increased susceptibility to typhoid fever (1). Gilchrist et al. (2) now provide evidence that the A allele is also associated with increased risk for bacteremia, and the association was driven primarily by nontyphoidal Salmonella , Streptococcus pneumoniae , Escherichia coli , and Acinetobacter , but not by Staphylococcus aureus, β-hemolytic streptococci, or Haemophilus influenza type b. Future studies are necessary to further validate the association between VAC14 and infectious diseases, determine the molecular mechanisms of protection, and investigate the … [↵][1]1To whom correspondence should be addressed. Email: dennis.ko{at}duke.edu. [1]: #xref-corresp-1-1