Impact of bacille calmette-guérin revaccination on serum IgE levels in a randomized controlled trial

Abstract

Introduction: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. Methods: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial. Results: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels. Conclusions: BCG responsiveness does not affect protection against atopy.