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AAV-mediated gene delivery to the lung

Humana Press Inc., (2019), 361-372
DOI: 10.1007/978-1-4939-9139-6_21
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Abstract

Adeno-associated virus (AAV) vectors are an efficient method of gene delivery to various tissues including the lung. Mouse models are often used as a preliminary preclinical model in order to advance AAV lung gene therapy vectors. In this chapter we describe an AAV purification protocol using heparin affinity chromatography as well as an intranasal and intratracheal method of delivering AAV vectors to the lungs of mice.

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van Lieshout, L. P., Domm, J. M., & Wootton, S. K. (2019). AAV-mediated gene delivery to the lung. In Methods in Molecular Biology (Vol. 1950, pp. 361–372). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9139-6_21

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