Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas

Abstract

High grade glioma (HGG) patients present with variable impairment in neurocognitive function (NCF). Based on that Isocitrate dehydrogenase 1 (IDH1)- wild type HGGs are more aggressive than IDH1-mutant type ones we hypothesized that patients with IDH1-wild type HGG would exhibit more severe NCF deficits than their IDH1-mutant counterparts.NCF assessed by Mini Mental Status Exam (MMSE), Trail Making Test (TMT), Digit Span (DS), and Controlled Word Association Test (COWAT) tests in 147 HGG patients preoperatively.Analyses between IDH1 groups revealed a significant difference, on MMSE concentration component (p= <0.01), and with MMSE concentration (r= -.401, p<0.01), TMTB (r=-.328 p .05) between the two IDH1 mutation subgroups of grade IV tumor patients. On the contrary, grade III group showed a significant difference in TMTB (p