Novel synthesis, characterization, antibacterial evolution & molecular modeling of Schiff base derived from R-camphor & five antibiotics from third generation of cephalosporin

Abstract

This paper included synthesis of five new novel Schiff bases from the condensation reaction of R-camphor and five cephalosporin third generation (cefotaxime, ceftazidem, ceftraixone, cefdinir, and cefexime, which is commonly use as antibiotic) in methanolic solution, in the presence of acid as catalyst. The prepared compounds identified by spectral methods (FT-IR, 1H-NMR, 13C-NMR), in addition to element analysis C.H.N., its biological activity has also been tested against some bacteria (S.aureus, E.Coli and P. aregionsa), all the compound (derivatives) have highest antibacterial activity than original drugs; Also molecular-docking were done to identify the appropriate binding of this compound, these compounds have more effectiveness than the original drugs.