Recent progress in the synthesis of tamiflu

Abstract

Tamiflu, one of the most common orally drugs for the treatment and prevention of influenza, has attracted extensive interests of synthetic chemists all over the world. Concise, efficient, and scalable synthetic approaches toward this molecule have been a very active field in recent years, and many diverse synthetic routes have been developed to date. In this review, representative synthetic routes employing chiral starting material or catalytic asymmetric reactions are briefly summarized. © 2013 Chinese Chemical Society & SIOC, CAS.