The application and research progress of ZIF-8 nanomaterials in biomedicine

Abstract

As a subclass of metal organic frameworks (MOFs), Zeolitic Imidazolate Framework 8 (ZIF-8) can be formed by self-assembly of zinc ions and 2-methylimidazole under simple conditions. Taking advantage of its acid sensitivity, high loading capacity and easy functionalization, ZIF-8 has a wide range of applications in biomedical fields. ZIF-8 is an ideal carrier for controlled drug transport and release, as it can efficiently transport not only small molecules for antibacterial and antitumor applications, but also It can act as a protective layer for peptides and other biological macromolecules, as well as modify the surface of implants and be used to assist in vivo bioimaging. Based on this, this paper reviews the applications and progress of ZIF-8 in the biomedical field and provides an outlook.