Incidence of Hyponatremia and Associated Factors in Preterm Infants in Saudi Arabia

Abstract

OBJECTIVE: To investigate the incidence of hyponatremia in preterm infants. The secondary aim was to determine the risk factors of late-onset of hyponatremia (LOH) and their influence on neonatal outcomes., STUDY DESIGN: The present study is a retrospective cohort study of 71 preterm infants born before 32 weeks of gestation at King Abdulaziz University Hospital and admitted to the neonatal intensive care unit, level 3, from January to December 2019. Hyponatremia was defined as a sodium level < 0.001) and higher risks of extra-uterine growth retardation (p = 0.007), CLD (p < 0.001), and sepsis (p = 0.001)., CONCLUSION: Twenty-seven percent of preterm infants in King Abdul Aziz University Hospital are born with or develop hyponatremia. Risk factors significantly associated with LOH included lower gestational age, lower birth weight, exclusive breastfeeding, long-term TPN, and prescribed diuretics and antibiotics. Possible outcomes of hyponatremia were long-term hospital stays, growth retardation, sepsis, and CLD. Copyright © 2022, Bamehrez et al.