Abstract
A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading. © 2008 Wiley Periodicals, Inc.
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CITATION STYLE
Barocas, V., William, D., Girton, T., Guler, I., Knapp, D., Moeller, J., & Parsonage, E. (2009). A dissolution-diffusion model for the TAXUSTM drug-eluting stent with surface burst estimated from continuum percolation. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 90(1), 267–274. https://doi.org/10.1002/jbm.b.31282
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