Hyperpolarized Solvatochromic Nanosensors towards Heparin Sensing in Blood

Abstract

Heparin quantification at the patient’s bedside has been of medical interest for years but a suitable point of care measurement method for whole blood is still elusive. Our group has recently developed a nanoparticlebased optical sensor for protamine that allows for heparin quantification in plasma. This work discusses the effect of the transducing-dye structure and the promise of embedding the sensors in an agarose gel to avoid red blood cell interference.