Natural products in drug discovery: Antibacterial and antifungal activity of essential oil of compound isolated from senecio royleanus

Abstract

Natural products are an excellent source of therapeutic products which has led to the discovery of many important drugs that play an important role in the treatment of various human diseases. In this current study two compounds has been isolated from Senecio royleanus DC. (Asteraceae) were undertaken for antibacterial and antifungal activity against five bacterial and fungal pathogens. The compounds isolated from Senecio royleanus, viz; 1,10β-epoxy 6-oxo-furanoeremophilan and 1β, 10-epoxy-furanoeremophilan displayed a very important role against all bacterial and fungal strains. 1,10 β-epoxy 6-oxo-furanoeremophilan showed maximum antibacterial activity against Agrobacterium tumefaciens (13 mm). While it showed maximum fungal activity against Fusarium oxysporum (15 mm). 1β,10-Epoxy-furanoeremophilan was found inactive in antibacterial activity against Escherichia coli, and showed maximum zone of inhibition against bacterial strain of Bacillus subtilis (12 mm) . It showed 12 mm zone against Rhizoctonia solani during antifungal activity. The fractions which showed significant antimicrobial activity i.e. (zoi ≥ 10 mm), were further tested to find out minimuminhibitory concentration and minimum bactericidal concentration at different concentrations.