Examination for anti human immunodeficienvy virus—type 1 (hiv-1) effect of three 4-hydroxycoumarin (4-hc) derivatives

Abstract

Seventeen 4-hydroxycoumarin derivatives have been synthesized and studied for anti-HIV activity. Three out of them (IM-7, IM-8 and IM-10) showed an effect on HIV replication in acutely infected cells by microtiter infection assay. The same substances demonstrated no impact on early stages of HIV-1 replication cycle. Structurally, all three 4-hydroxycou-marins were positional isomers of di- and tri-methoxy-4-hydroxycoumarin, probably conferring their anti-HIV activity. Studies are in progress to further elucidate the exact target of anti-HIV activity. © 2005 Taylor and Francis Group, LLC.