High sensitive immunoelectrochemical measurement of lung cancer tumor marker ProGRP based on TiO2-Au nanocomposite

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Abstract

Progastrin-releasing peptide (ProGRP), which is known to be highly specific and sensitive to small cell lung cancer (SCLC), has been proven to be a valuable substitute for neuron-specific enolase in SCLC diagnostics and monitoring, especially in its early stages. The detection of ProGRP levels also facilitates a selection of therapeutic treatments. For the fabrication of our proposed biosensor, titanium (IV) oxide microparticles were first used, followed by dispersing gold nanoparticles into chitosan and immobilizing them onto a carbon paste electrode (CPE) surface. The developed immunosensor exhibits a much higher biosensing performance in comparison with current methods, when it comes to the detection of ProGRP. Therefore, the proposed CPE/TiO2/(CS+AuNPs)/anti-ProGRP/BSA/ProGRP is excellent for the development of a compact diagnostics apparatus.

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Wei, Z., Cai, X., Zhang, J., Fan, J., Xu, J., & Xu, L. (2019). High sensitive immunoelectrochemical measurement of lung cancer tumor marker ProGRP based on TiO2-Au nanocomposite. Molecules, 24(4). https://doi.org/10.3390/molecules24040656

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