ICAM-1 and MKL-1 polymorphisms impose considerable impacts on coronary heart disease occurrence

Abstract

This study was aimed to explore the correlation of intercellular adhesion molecule-1 (ICAM-1) K469E and megakaryoblastic leukaemia factor-1 (MKL-1) −184C/T polymorphisms with the susceptibility to coronary heart disease (CHD) in the Chinese Han population. 100 CHD patients and 91 healthy people that had no blood connection with each other were enrolled in this case-control study. ICAM-1 and MKL-1 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. Multiple logistic regression was used to analyse the correlation between polymorphisms of ICAM-1 and MKL-1 and CHD susceptibility. Differences of genotype and allele frequencies of the two SNPs between case and control groups were analysed by chi-square test. Odds ratios (ORs) and 95% confidence intervals (CIs) were indicated relative susceptibility of CHD. The distributions of ICAM-1 and MKL-1 polymorphisms in each group conformed to Hardy-Weinberg equilibrium (HWE). After adjusting for traditional risk factors, the TT genotype frequency of MKL-1 −184C/T polymorphism was found significantly higher in case group than in control group (P