Deficient hippocampal insulin signaling and augmented tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: A study in Zucker rats

30Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Insulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-induced peripheral insulin resistance and aging are risk factors for central insulin resistance and whether central insulin resistance is related to the pathologic phosphorylation of the Tau protein. Results: Aging and obesity significantly attenuated the phosphorylation of the insulin cascade kinases Akt (protein kinase B, PKB) and GSK-3β (glycogen synthase kinase 3β) in the hippocampi of the fa/fa rats. Furthermore, the hyperphosphorylation of Tau Ser396 alone and both Tau Ser396 and Thr231 was significantly augmented by aging and obesity, respectively, in the hippocampi of these rats. Conclusions: Both age-induced and obesity-induced peripheral insulin resistance are associated with central insulin resistance that is linked to hyperTau phosphorylation. Peripheral hyperinsulinemia, rather than hyperglycemia, appears to promote central insulin resistance and the Tau pathology in fa/fa rats.

Cite

CITATION STYLE

APA

Špolcová, A., Mikulášková, B., Kršková, K., Gajdošechová, L., Zórad, Š., Olszanecki, R., … Maletínská, L. (2014). Deficient hippocampal insulin signaling and augmented tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: A study in Zucker rats. BMC Neuroscience, 15(1). https://doi.org/10.1186/1471-2202-15-111

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free