Evaluation of Platelets Count and Indices in Pre-Eclampsia Compared to Normal Pregnancies

Abstract

Background/Aim: Pre-eclampsia (PE) and eclampsia are major obstetric problem in developing countries and remains an important cause of maternal mortality worldwide. The study aimed to evaluate/compare the platelet count and platelet indices in pre-eclampsia and normal pregnancies Methods: This prospective case control study was conducted in Khartoum state at Omdurman Maternity Hospital, during the period from March to June 2016. Pregnant women (N/87) with 28 weeks' gestation or more who attended at antenatal care unit or admitted into the Department of Obstetrics and Gynecology, were selected as population of the study. Among them 37 patients with either mild or sever PE, 50 normal pregnancies as controls were enrolled. EDTA-venous blood sample was collected from each patient and control for platelet count and platelet indices measurement by automated blood cells counter (SYSMEX-KX 21). Results: In the present study the mean platelet counts was 236.16±82.33, 261.34 ±62.69 X10 9 /L in patients and controls respectively. The mean MPV was 10.15±1.10 and 9.48±0.87/fl, whereas mean PDW was 13.37±2.84, 12.15±2.35 /fl as well as mean P-LCR% was 26.71±7.87, 22.32±6.52% in patients and controls respectively. The present study found that MPV(P; 0.02), PDW (P; 0.03) and P-LCR (P; 0.05) of PE group was significantly higher than normal group. The platelets count (P; 0.1) and plateletcrit (PCT%) (P; 0.64) were lower in PE group but didn't show significant variation. Conclusion: Platelet indices of MPV, PDW and P-LCR increases in PE in comparison to normal pregnancy Key.