Synthesis of cycloheptanoid natural products via a tandem 5-exo-cyclization/Claisen rearrangement process

Abstract

This article describes the development of a microwave-assisted oxyanionic 5-exo-dig cyclization-Claisen rearrangement sequence as a convenient one-pot route to a variety of seven-membered carbocyclic ring systems. This process was used as the key transformation for the construction of several natural products, including frondosins A, B and C. © ARKAT-USA, Inc.