Actualización bibliográfica sobre el uso de preparaciones ricas en plaquetas en la cicatrización de heridas

Abstract

Platelets store more than 20 growth factors in their granules. Their secretion promotes wound healing and repair. The intricate wound healing process involves not only the angiogenic platelet factors but also de anti-angiogenic ones. The process of platelet preservation, such as freezing, disrupt the platelet membrane structure and their angiogenic properties causing platelet activation. In the field of wound healing and the management of recalcitrant wounds in debilitated and chronically ill patients, there have been several studies. These studies have focused on the use of the different platelet preparations such as fresh frozen plasma, frozen-dried platelet rich plasma, sonicated platelet rich plasma and the use of alogenic acelular dermis. Platelet preparations posses positive effects on wound healing with little alterations of the final scar tissue. In this article we will describe and discuss the studies that have involved the use of these platelet rich preparations in the filed of wound healing and we will also state the road blocks and the studies that will come in the near future regarding the use of platelets products in the field wound healing.