A clinical study of intravenous anaesthesia with a eugenol derivative, G.29.505

Abstract

Summary: A dervative of eugenol, G.29.505, was given intravenously to induce anaesthesia in 100 adult patients for operations ranging from minor gynaecological procedures to pneumonectomies and gastrectomies.The grug when given in a 5 per cent solution produced with a transient respiratory stimulation followed by a brief of apnoen. No significant effect were observed on the rate aand rhythm of the heart, on blood pressure, or on cardiac output. There was, however, an increase in skin blood flow as measured by digital plethysmography.Thirty-three patients developed venous thrombosis around the site of injection and this incidence is too high to justify its use except in special circumstances. © 1962 John Sherratt and Son.