Imageable antigen-presenting gold nanoparticle vaccines for effective cancer immunotherapy in vivo

Abstract

Delivery tracking: Goldnanoparticles (AuNPs) were functionalized with a red fluorescent protein (RFP, pink shapes in picture) as model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized AuNPs were used as cancer vaccines in a tumor model, where they enabled efficient delivery of an antigen to target sites, tracking of the vaccines using noninvasive clinical imaging, and cancer prevention and therapy. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.