The effect of cinnamon (Cinnamomum burmannii) leaf extract gel on the number of fibroblasts in healing inflammation of the oral mucosa of white wistar

Abstract

Cinnamon leaves contain flavonoids, alkaloids, steroids and tannins that can help stimulate fibroblast cell formation and inhi-bit bacterial growth with antibacterial, antioxidant and anti-inflammatory activities so as to accelerate the healing process in inflammation. This study aims to determine the optimal concentration of cinnamon leaf extract gel (Cinnamomum burman-nii) 35% on the number of fibroblast cells in healing inflammation of the buccal mucosa of wistar strain white rats (Rattus nor-vegicus). Laboratory experimental research in vivo with randomised post-test only control group design using 30 wistar rats which were divided into three groups: positive control (K+) given H2O2 30% + Aloclair gel; negative control (K-) given H2O2 30%, and the third group (P) given H2O2 30% + 35% DKM extract gel. The results showed the mean number of fibroblast cells in groups (K+), (K-), and (P) were 51.1 cells, 29.1 cells, and 43.8 cells, respectively. All groups showed significantly dif-ferent results (????<0.05) with the one-way Anova test. It is concluded that 35% DKM extract gel can increase the number of fi-broblast cells so that it can effectively heal the inflammation of the buccal mucosa of white wistar rats.