Enhanced bioaccumulation of fluorinated antibiotics in crucian carp (Carassius carassius): Influence of fluorine substituent

Abstract

The negative impact of residual fluorinated antibiotics on the ecosystem and human health are of great concern. However, only a few studies have been conducted on the factors that influence the bioaccumulation of fluorinated antibiotics in aquatic organisms. To investigate the effects of fluorine substituent, environmental concentration of antibiotics, and temperature on the bioaccumulation of florfenicol (FLO), thiamphenicol (TAP), ofloxacin (OFX), and pipemidic acid (PPA), crucian carp (Carassius carassius) were exposed to different concentrations of antibiotics and different temperatures for 21 days. The liver exhibited the highest antibiotic concentrations, with 315.4 ± 13.6 ng g−1 wet weight (ww), followed by the bile (279.4 ± 12.4 ng mL−1), muscle (53.1 ± 4.3 ng g−1 ww), and gills (37.1 ± 2.6 ng g−1 ww). The FLO and OFX containing the fluorine substituent were much easier to accumulate in crucian carp compared with their isonomic TAP and PPA, respectively. The fluorine substituent increased the bioaccumulation of the targeted antibiotics in crucian carp. In addition, the lower levels of antibiotics presented higher bioaccumulation potential, but the temperature had little effect on the bioaccumulation. These findings in the present study can provide further insight into the environmental behaviors and ecological risks of fluorinated antibiotics in the aquatic environment.