Omicron Breakthrough Infection after Heterologous Prime-Boost Vaccination Induces a Vigorous Antibody Response

Abstract

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is usually asymptomatic or mild and appears to be poorly immunogenic at least in unvaccinated individuals. Here, we found that health care workers vaccinated with 2 doses of Sputnik V and a booster dose of ChAdOx1 mount a vigorous neutralizing-Antibody response after Omicron breakthrough infection.