Pten regulates zebrafish hematopoiesis

Abstract

In this issue of Blood, Choorapoikayil et al have used phosphatase and tensin homolog (Pten)-deficient zebrafish to uncover prominent roles for Pten loss in enhancing proliferation of hematopoietic stem cells (HSCs) and eliciting differentiation arrest within lineage-committed blood progenitor cells. These results provide novel insights into the early genetic events that predispose blood cells to malignant transformation.1 ©2014 by The American Society of Hematology.