Viscous topical is more effective than nebulized steroid therapy for patients with eosinophilic esophagitis

Abstract

We performed a randomized trial to compare nebulized and viscous topical corticosteroid treatments for eosinophilic esophagitis (EoE). Subjects with incident EoE (n = 25) received budesonide 1 mg twice daily, either nebulized and then swallowed (NEB) or as an oral viscous slurry (OVB), for 8 weeks. Baseline eosinophil counts for the NEB and OVB groups were 101 and 83 (P =.62). Posttreatment counts were 89 and 11 (P =.02). The mucosal medication contact time, measured by scintigraphy, was higher for the OVB group than the NEB group (P