Discovery and Chemical Development of the Use-Dependent Sodium Channel Blocker Vixotrigine for the Treatment of Pain

Abstract

Case Studies from the Pharmaceutical Industry. Describing the continuum from discovery to development, readers will learn how recent drugs, including grazoprevir, melflufen, relebactam, and tesirine, were developed. This work highlights emerging concepts, new developments, and challenges during the discovery process. Well-known authors from the pharmaceutical industry provide an inside look to traditionally closed-door procedures. Chemists in industry and academia alike will find these accounts valuable.