Abstract
A simple reordering of the reaction sequence allowed the improved synthesis of EIDD-2801, an antiviral drug with promising activity against the SARS-CoV-2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17 % to 61 %, and fewer isolation/purification steps were needed. In addition, a continuous flow procedure for the final acetonide deprotection was developed, which proved to be favorable toward selectivity and reproducibility.
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Steiner, A., Znidar, D., Ötvös, S. B., Snead, D. R., Dallinger, D., & Kappe, C. O. (2020). A High-Yielding Synthesis of EIDD-2801 from Uridine**. European Journal of Organic Chemistry, 2020(43), 6736–6739. https://doi.org/10.1002/ejoc.202001340
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