Glutathione S-transferases Detoxify Endogenous and Exogenous Toxic Agents- Minireview

Abstract

Glutathione S-transferases (GSTs) are belongs to phage II detoxification enzymes which play an important role in detoxification/biotransformation of endogenous and exogenous toxic agents like reactive oxygen species (ROS), reactive nitrogen species (RNS) and xenobiotic including environmental carcinogens. The generation of reactive oxygen/nitrogen species is known as oxidative stress which causes molecular damage. Oxidation of proteins leads to loss of certain function. Oxidation of lipids causes the disruption of biological membrane. That the DNA mutation and oxidative DNA lesions which are critical in carcinogenesis. This mini review discussed about the detoxification role of GSTs against endogenous and exogenous toxic compounds.