Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol

Abstract

An enantioselective synthesis and resolution of the key White intermediate (3) for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (2) by an olefination reaction of 3 and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported.