Synthesis of Substituted 7,7′-bis-Indolizines via 1,3-Dipolar Cycloaddition under Microwave Irradiation

Abstract

An efficient method for preparation of substituted 7,7′-bis-indolizines, based on 1,3-dipolar cycloaddition of 4,4′-bipyridinium ylides generated in situ with activated', alkynes, is proposed. The reaction was carried out in good yields by microwave irradiation and KF/alumina under solvent-free conditions.