Antiproliferation effects of Glycine max Linn ethanolic extract on induced mammary gland carcinoma in albino rats

Abstract

This study aimed to determine the antiproliferation effect of Glycine max Linn ethanolic extract on Sprague Dawley albino rats induced by 7,12-dimethylbenz(á)anthracene (DMBA) on the mammary gland. This study used 20 albino rats then divided into five treatment groups, i.e., positive control (C+) induced DMBA; negative control (C-) none treatment; Treatment groups (T1; T2; T3) induced DMBA then followed extract dose (5; 10; 20 mg/day). DMBA induction was given every two days for 20 days subcutaneously. Administration of Glycine max Linn extract was given peroral for 14 days. It can be concluded that Glycine max Linn ethanolic extract inhibits the proliferation cell in mammary gland carcinoma in albino rats revealed on aspect hyperchromatization, tubular formation, and shape of the nuclei.