A sugar rush of DNA methylation

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Abstract

A new study in Nature identifies a molecular axis linking diabetes to cancer, whereby AMPK, which is inhibited in high glucose conditions, regulates the stability of TET2 DNA demethylase, thereby impacting DNA methylation and gene expression.

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Strzyz, P. (2018, October 1). A sugar rush of DNA methylation. Nature Reviews Molecular Cell Biology. Nature Publishing Group. https://doi.org/10.1038/s41580-018-0051-9

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