A multifunctional ribonuclease-A-conjugated CdTe quantum dot cluster nanosystem for synchronous cancer imaging and therapy

Abstract

CdTe quantum dot (QD) clusters are synthesized in the presence of RNase A, which acts as a biomolecular templating, agent under microwave irradiation. Red shifts of photoluminescence spectra of the denatured RNase A (dRNase A)-capping QD clusters (dRQDs) are detected during a fifty-day storage period at room temperature. Native RNase-A-associated dRQDs (R-dRQDs) are functionalized with cyclic RGD peptides for synchronous targeted cancer imaging and therapy. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.