A chemical approach to "rewire" neural progenitor cells

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Abstract

Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors. © 2014 IBCB, SIBS, CAS All rights reserved.

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Wu, M. Z., Li, M., Liu, G. H., & Belmonte, J. C. I. (2014). A chemical approach to “rewire” neural progenitor cells. Cell Research, 24(6), 641–642. https://doi.org/10.1038/cr.2014.51

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