1086 CBT-I FOR MENOPAUSE RELATED INSOMNIA ALSO REDUCES DEPRESSION SEVERITY

Abstract

Introduction: Menopause has been associated with elevated risk of mood disturbances. This relationship has been attributed to a number of factors including alterations in hormone levels, psychosocial factors, and insomnia associated with menopause. While cognitive behavioral therapy for insomnia (CBT‐I) has been shown to also reduce depression in the general population, the effectiveness of CBT‐I in reducing depression associated with menopause has not been tested. Methods: 122 females with insomnia concurrent with menopause were randomized into three conditions: CBT‐I (N=41), Sleep Restriction Therapy (SRT, N=41) and an Information‐only control condition (IC, N=40). Outcome measures included Insomnia Severity Index (ISI), and Beck Depression Inventory (BDI‐II; sans sleep items). All measures were conducted pre‐, post‐treatments, and at 6 months follow‐up. Results: dCBT‐I resulted in a robust significant improvement in ISI (‐8.2 ± 5.3 points) compared to control (‐4.0 ± 4.2 points). The post‐treatment remission rate (ISI≤10) was significantly greater in the dCBT‐I condition (67.1%) compared to the control group (33.7%; p .05), the dCBT‐I condition exhibited a significantly lower rate of clinically significant depression at post‐treatment (8.2%) compared to the control group (19.0%, p