Process validation for production of copper radioisotopes in a TR-19 variable energy cyclotron

Abstract

64Cu is a cyclotron-produced radionuclide suitable for positron emission tomography (PET) and internal radiotherapy. We have been focused on 64Cu radioisotope due to its favorable nuclear characteristics (β+ emission, 18% and β- emission, 39%). Moreover, the electron capture (43%) implies Auger electron emission with high linear energy transfer in the targeted cells. Also, the 12.7 hours half-life allows a good uptake and distribution of the radiopharmaceuticals to obtain qualitative images with high contrast. The production of no-carrier-added 64Cu via the 64Ni(p,n)64Cu nuclear reaction using a variable energy cyclotron (TR-19, ACSI, Canada) was studied in our work involving the implementation of a fully automated solid target irradiation and processing system. In this paper we report the validation of the process for the automated production and purification of 64Cu produced in a variable energy (14-19 MeV) cyclotron, using a commercially available automated solid target system (ALCEO, Comecer S.p.A, Italy), comprising modules for electrodeposition, pneumatic transfer, irradiation unit, dissolving and purification. The obtained 64CuCl2 solution complies with the requirements of a radiopharmaceutical for medical applications. The process is to be translated for production of other copper radioisotopes of medical interest.