Zinc supplementation improves bone density in patients with thalassemia: A double-blind, randomized, placebo-controlled trial

Abstract

Background: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass Objective: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal Design: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray absorptiometry, and fasting blood was collected for the measurement of plasma zinc at 0, 12, and 18 mo Results: Thirty-two subjects, 81% of whom were transfusion dependent, completed the study (mean 6 SD: 17.1 6 5.2 y). Plasma zinc was #70 mg/dL in 11 subjects at baseline and increased significantly with zinc supplementation (P = 0.014). Use of intentionto- treat analysis and linear models for longitudinal data, adjusted for baseline and pubertal stage, showed that the zinc group had significantly greater increases in whole-body BMC (adjusted mean 6 SE: 63 6 15 g; P = 0.02), and aBMD (0.023 6 0.006 g/cm2; P = 0.04) than did the placebo group after 18 mo. Furthermore, adjusted spine and hip aBMD z scores each decreased by 0.3 SDs (both P = 0.04) in the placebo compared with the zinc group over the 18-mo study Conclusions: In young patients with Thal, zinc supplementation resulted in greater gains in total-body bone mass than did placebo Zinc was well tolerated and is worthy of investigation in larger trials in Thal patients across a range of ages and disease severity. © 2013 American Society for Nutrition.