Prevention of HER-2/neu transgenic mammary carcinoma by tamoxifen plus interleukin 12

24Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

FVB-NeuN (N#202) female mice transgenic for the HER-2/neu protooncogene driven by the murine mammary tumor virus (MMTV) promoter develop mammary carcinomas with a progression from focal atypical hyperplasia to in situ carcinoma and to invasive carcinoma that closely resembles that of human neoplasia. Here we report that the combination of tamoxifen plus interleukin 12 (IL-12) results in a very effective prevention of mammary carcinogenesis, significantly higher than those obtained with either tamoxifen or IL-12 alone. At I year of age, 20% of control mice resulted tumor-free, whereas 80% of mice receiving the combined treatment were tumor-free. At 2 years of age, less than 5% of control mice were tumor-free, as opposed to 70% of mice treated with tamoxifen plus IL-12. The combined treatment inhibited mammary carcinogenesis mainly through a reduction in the number of mammary cells at risk of progression, a reduction in estrogen receptors (ERs) expression and a reduction in the angiogenic support to mammary development, likely due to cross-talk between tamoxifen and interferony (IFNy) (the main downstream mediator elicited in vivo by IL-12). The addition of IL-12 to the tamoxifen treatment more than doubled mouse lifetime and did not exacerbate known side effects of tamoxifen. © 2003 Wiley-Liss, Inc.

Cite

CITATION STYLE

APA

Nanni, P., Nicoletti, G., De Giovanni, C., Landuzzi, L., Di Carlo, E., Iezzi, M., … Lollini, P. L. (2003). Prevention of HER-2/neu transgenic mammary carcinoma by tamoxifen plus interleukin 12. International Journal of Cancer, 105(3), 384–389. https://doi.org/10.1002/ijc.11092

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free