IGSF3-mediated potassium dysregulation promotes neuronal hyperexcitability and glioma progression

Abstract

Glioblastomas are incurable tumors often associated with epileptic seizures. In a recent study published in Neuron, Curry et al. demonstrated a novel function of the membrane protein IGSF3 that induces potassium dysregulation, neuronal hyperexcitability, and tumor progression. This work uncovers a novel layer of bidirectional neuron–tumor communication, further underlining the importance of comprehensively investigating neuron–tumor networks in glioblastoma.